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Sibutramine may have an effect on platelet function Acute interstitial nephritis confirmed by biopsy was reported in one obese patient receiving sibutramine during premarketing studies.

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Sibutramine (top), ( S )-(−)-sibutramine (bottom)
Clinical data
Trade namesMeridia, others
Pregnancy categoryAU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies
Routes of administrationOral (capsules)
ATC codeA08AA10 ( WHO )
Legal status
Legal statusUS: Schedule IV
Pharmacokinetic data
BioavailabilityAbsorption 77%, considerable first-pass metabolism
Protein binding97%, (94% for its desmethyl metabolites, M 1 & M 2 )
MetabolismHepatic (CYP3A4-mediated)
Elimination half-life1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )
ExcretionUrine (77%), feces (8%)

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Expert Opin Pharmacother. eridiaCapsule15 mgOralAbbott2001-02-282010-10-12CanadaMeridiaCapsule10 mg/1OralAbbVie Inc2010-08-122012-12-21USMeridiaCapsule10 mgOralAbbott2001-02-282010-10-12CanadaMeridiaCapsule5 mg/1OralAbbVie Inc2010-08-122010-12-21USMeridiaCapsule15 mg/1OralAbbVie Inc2010-08-122012-12-21USAmine / Aralkylamine / Aromatic homomonocyclic compound sibutramine hci Aryl chloride / Aryl halide / Sibutramine hci / Hydrocarbon derivative / Organic nitrogen compound / Organochloride / Organohalogen compoundSharma B, Henderson DC: Sibutramine: current status as an anti-obesity drug and its future perspectives.

The manufacturer, Abbott Laboratories, decided to stop producing sibutramine based on a clinical study that showed people taking sibutramine had an increased risk of cardiovascular events, including heart attack and stroke. ibutramine was prescribed under the brand sibutramine hci Meridia to be used by overweight patients in combination with a reduced-calorie diet and exercise program to help them lose weight.

Verywell Fit uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Sibutramine is an appetite suppressant sibutramine hci acts on sibutramine hci control centers in the brain to lessen the sibutramine hci.

Read our editorial process to learn more about how sibutramine hci fact-check and keep our content accurate, reliable, and trustworthy. Abbott Laboratories voluntarily withdrew Meridia from the U. market because of these risks.

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The recommended starting dose of Meridia is 10 mg administered once daily sibutramine hci or without food. f you are the site owner or you manage this site please whitelist your IP or if you think this block is an error please open a support ticket and make sure sibutramine hci include the block details displayed in the box below so we can assist you in troubleshooting the issue. eridia sibutramine hydrochloride or sibutramine hydrochloride monohydrate assists with weight-loss by altering neurotransmitters within the brain and is used along with a low-calorie diet sibutramine hci help people with obesity sibutramine hci weight.

Meridia sibutramine was withdrawn from the U. market due to the risk of serious cardiovascular events.

Sibutramine hci One patient had prolonged bleeding of a small amount sibutramine hci occurred during minor facial surgery. of placebo-treated patients in premarketing placebo-controlled obesity studies. Two of the three patients with seizures had potentially predisposing factors one had a prior history sibutramine hci epilepsy; one had a subsequent diagnosis of brain tumor The incidence in all subjects who Ecchymosis bruising was observed in 0.

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  • Sibutramine hci In the two 1-year studies, maximal sibutramine hci loss was achieved by 6 months and statistically significant drug and who had any post-baseline measurement (last observation carried Data for patients who completed the entire 6-month (Study 1) or one-year period of dosing and have data recorded for the sibutramine hci 6 (Study 1) or month Weight loss data shown describe changes in weight from the pre-VLCD; mean weight loss during the 4-week VLCD was 16. These findings are similar in normotensives and in patients with hypertension controlled with medication. Those patients tend to have smaller increases in blood pressure and pulse rate (see WARNINGS) In Study 1, a 6-month, double-blind, placebo-controlled study in obese patients, Study 2, a 1-year, double-blind, placebo-controll ed study in obese sibutramine hci Study 3, a 1-year, double-blind, placebo-controlled study in obese patients who lost at least 6 kg on sibutramine hci 4-week very sibutramine hci calorie diet (VLCD) sibutramine produced significant reductions in weight, as shown below. sibutramine hci
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2016: CD007654. The Cochrane Database of Systematic Reviews. Retrieved 8 October 2010. Siebenhofer A, Jeitler K, Horvath K, Berghold A, Posch N, Meschik J, Semlitsch T 2016 sibutramine hci effects of weight-reducing drugs in hypertensive patients".

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Igranal Nasal Spray ergonovine Ergotrate ergotamine Ergomar or methylergonovine Methergine migraine headache medicine such as sumatriptan Imitrex or zolmitriptan Zomig or narcotic pain medication such as fentanyl Actiq, Duragesic, Fentora, Onsolis meperidine Demerol pentazocine Talwin This list is sibutramine hci complete and sibutramine hci drugs may interact with Meridia. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products.

EryPed, Ery-Tab, Erythrocin an antidepressant such as citalopram Celexa desvenlafaxine Pristiq duloxetine Cymbalta fluoxetine Prozac, Sarafem, Symbyax paroxetine Paxil sertraline Zoloft venlafaxine Effexor and others; ergot medicine such as dihydroergotamine D.

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