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See discussion under Factor Five. Berger, et al. Dr. Jasinski metaxalone schedule opined that the finding that bemegride, a non-specific barbiturate antagonist, apparently reduced the amplit udeof carisoprodol-mediated currents by 24% oes notindicate that carisoprodol will have barbiturate like effects. Metaxalone schedule Dr. Jasinski may be correct that the findings of the aforementioned study do not conclusively establish that carisoprodol has barbiturate-like effects, there is substantial other evidence in the record including human studies which supports this finding.

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Dr. Jasinski also noted that in his experience as the Chief of the Center for Chemical Dependence at Johns Hopkins Bayview Medical Center, he could not recall a single incidence in which an individual has visited our center to be treated for carisoprodol addiction/dependence. While Meda cites human data in particular, the results of recent clinic trials it conducted and the Fraser study and argues that this data should be given greater weight than the animal studies, as discussed below, both studies have significant limitations. ...