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Pronunciation/ ˌ m ɛ l ə ˈ t oʊ n ɪ n / ( listen )
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AHFS/Drugs.comConsumer Drug Information
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    The generation and regulation of sleep that arises from multiple brain regions, neurotransmitter systems and modulatory hormones is driven by a complex interaction of wake and sleep mechanisms involving: (a) a wake-dependant homeostatic buildup of sleep pressure that increases with prolonged wakefulness and dissipates during sleep; and (b) a 24 h body clock or circadian system (circa diem - about a day) that aligns sleep to the dark phase and activity to the light phase of the 24 h day through precisely controlled, cyclic expression of a number of genes, so-called clock genes. Sleep is only part of the 24 h circadian cycle. ...

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