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Clinical data
Trade namesCymbalta, others [1]
License dataEU  EMA:  by INN, US   FDA: duloxetine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSerotonin–norepinephrine reuptake inhibitor
ATC codeN06AX21 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~ 50% (32% to 80%)
Protein binding~ 95%
MetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A2
Elimination half-life12 hours
Excretion70% in urine, 20% in feces

Withdrawal effects vary individually. However, withdrawal symptoms from Cymbalta are so common that doctors have given the symptoms their own term: Cymbalta Discontinuation Syndrome. In fact, hundreds of law suits have been filed against Cymbalta 60 mg high Lilly, the makers of Cymbalta, claiming that they downplayed or failed to state that withdrawal symptoms associated with Cymbalta were common and significant.

Some experts estimate roughly 50% of people discontinuing Cymbalta will have withdrawal symptoms. Most antidepressant drugs are associated with some withdrawal symptoms. Numerous studies have proven its worth, but just cymbalta 60 mg high significant are its potential harms?

Y M. was supportive, - resorted to hydrocodone. It worked, but I hated taking opiates. Cymbalta . -Fluoxetine. Prozac. -Paroxetine. Paxil. -Propafenone. -Quinidine. -Ritonavir. No studies showing that Tylenol #3 interacts w/ Warfarin, but studies ... Both DULoxetine and phenylephrine can increase blood pressure and heart rate, and combining them may enhance these effects.

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Discontinuation symptoms: Do not stop Cymbalta without first talking to your healthcare provider. Stopping Cymbalta too quickly or changing from another antidepressant too quickly may result in serious symptoms including: Only some people cymbalta 60 mg high at risk for these problems. ...

or serotonin norepinephrine reuptake inhibitors SNRIs such as desvenlafaxine Khedezla, Pristiq, duloxetine Cymbalta , and venlafaxine Effexor XR. If you had enjoyed some symptom relief with a medication, it's important to make a slow transition to a new drug to minimize the risk of a relapse.

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Decreased blood pressure upon standing, which can cause falls, dizziness or fainting, mostly when first starting or increasing the dose. Severe liver problems, some fatal, have been reported.

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Drugs. ll positive feedback so far. cymbalta 60 mg high Cymbalta 60 mg high That is a way to go off psychiatric drugs that increases the risk of withdrawal syndrome. Verall, between 1 in 6 and 1 in 5 persons experience a side effect.

Cymbalta 60 mg high But they also prevent serotonin particles that are released in a synapse from binding at certain undesired receptors and redirect them instead to other receptors that can help nerve cells within mood circuits function better. They prevent the reuptake of serotonin. They include duloxetine Cymbalta venlafaxine Effexor desvenlafaxine ER Khedezla levomilnacipran Fetzima and desvenlafaxine Pristiq Norepinephrine and dopamine reuptake inhibitors NDRIs are another class of reuptake inhibitors, but they're represented by only one drug: bupropion Wellbutrin It affects the reuptake of norepinephrine and dopamine.

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Australia — Duloxetine ( Cymbalta ®) is a serotonin and noradrenaline reuptake inhibitor recently approved for the treat- ment of major depressive disorder.

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