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Ref A 45-year-old female developed massive crystalluria, gross hematuria, and acute anuric renal failure after 12 days of intravenous amoxicillin-clavulanate at a dose of 2 g amoxicillin 3 times daily (not available in the United States) The crystals were composed of amoxicillin trihydrate. epatic cholestasis and acute cytolytic hepatitis have been reported with amoxicillin use. Ref Renal side effects have rarely included crystalluria, hematuria, acute renal failure, and acute interstitial nephritis, often associated with fever, rash, and eosinophilia. ...

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Tell the doctor right away if you develop: persistent diarrheaabdominal or stomach pain/crampingblood/mucus in your stool Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. ...

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Amoxicillin usually is continued for 60 days for postexposure prophylaxis or treatment of inhalational or cutaneous anthrax in the context of biologic warfare or bioterrorism. If amoxicillin is used in the treatment of infections caused by group A β-hemolytic streptococci, therapy should be continued for at least 10 days to decrease the risk of rheumatic fever and glomerulonephritis. Persistent infections may require several weeks of therapy. ...

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